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Cell‐Penetrating Homochiral Cyclic Peptides as Nuclear‐Targeting Molecular Transporters
Author(s) -
Mandal Deendayal,
Nasrolahi Shirazi Amir,
Parang Keykavous
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102572
Subject(s) - phosphopeptide , chemistry , conjugate , cyclic peptide , chromosomal translocation , transporter , cytoplasm , peptide , nucleus , biochemistry , microbiology and biotechnology , cancer research , biology , biophysics , gene , mathematical analysis , mathematics
Going round in circles : Amphipathic L ‐cyclic peptides facilitate the cellular uptake of fluorescently labeled lamivudine and a phosphopeptide. A corresponding fluorescently labeled conjugate F‐[W 5 R 4 K] showed a highly efficient translocation in the nucleus of colon adenocarcinoma, breast carcinoma, and human ovarian adenocarcinoma (see picture).