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Aplysqualenol A Binds to the Light Chain of Dynein Type 1 (DYNLL1)
Author(s) -
Vera Brunilda,
Rodríguez Abimael D.,
La Clair James J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102546
Subject(s) - dynein , chain (unit) , immunoglobulin light chain , type (biology) , chemistry , biophysics , physics , biology , microbiology and biotechnology , microtubule , genetics , ecology , astronomy , antibody
A bidirectional affinity system has been developed for the identification of cancer‐related natural products and their biological targets. Aplysqualenol A is thus selectively identified as a ligand of the dynein light chain. The use of forward and reverse affinity methods suggests that both small‐molecule isolation and target identification can be conducted using conventional molecular biological methods.