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Superhydrophobic–Superhydrophilic Micropatterning: Towards Genome‐on‐a‐Chip Cell Microarrays
Author(s) -
Geyer Florian L.,
Ueda Erica,
Liebel Urban,
Grau Nicole,
Levkin Pavel A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102545
Subject(s) - micropatterning , superhydrophilicity , dna microarray , microarray , cell , chip , nanotechnology , materials science , microbiology and biotechnology , chemistry , biology , gene expression , computer science , gene , wetting , biochemistry , telecommunications , composite material
High‐density cell microarrays based on superhydrophilic microspots separated by superhydrophobic barriers have been realized. The microspots absorb water solutions, while the barriers prevent cross‐contamination, thus allowing the spots to be used as reservoirs for transfection mixtures and preventing cell proliferation and cell migration between the microspots. The picture shows four cell types after two days of culturing on the microarray.