Premium
Artificially Induced Protein–Membrane Anchorage with Cholesterol‐Based Recognition Agents as a New Therapeutic Concept
Author(s) -
Avadisian Miriam,
Fletcher Steven,
Liu Baoxu,
Zhao Wei,
Yue Peibin,
Badali Daniel,
Xu Wei,
Schimmer Aaron D.,
Turkson James,
Gradinaru Claudiu C.,
Gunning Patrick T.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102486
Subject(s) - liposome , microbiology and biotechnology , membrane , motility , in vitro , chemistry , vesicle , membrane protein , biochemistry , biology
Keeping harm at bay : In an in vitro strategy to prevent the cellular motility of oncogenic STAT3 protein, protein–membrane anchorage was induced by the use of a rationally designed cholesterol‐based protein–membrane anchor in breast‐tumor cells. (The fluorescence image shows the localization of the protein to the liposome boundary of a multilamellar vesicle.)