Artificially Induced Protein–Membrane Anchorage with Cholesterol‐Based Recognition Agents as a New Therapeutic Concept | Zendy

Avadisian Miriam | Zendy; Fletcher Steven | Zendy; Liu Baoxu | Zendy; Zhao Wei | Zendy; Yue Peibin | Zendy; Badali Daniel | Zendy; Xu Wei | Zendy; Schimmer Aaron D. | Zendy; Turkson James | Zendy; Gradinaru Claudiu C. | Zendy; Gunning Patrick T. | Zendy

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Artificially Induced Protein–Membrane Anchorage with Cholesterol‐Based Recognition Agents as a New Therapeutic Concept

Author(s) -

Avadisian Miriam,

Fletcher Steven,

Liu Baoxu,

Zhao Wei,

Yue Peibin,

Badali Daniel,

Xu Wei,

Schimmer Aaron D.,

Turkson James,

Gradinaru Claudiu C.,

Gunning Patrick T.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201102486

Subject(s) - liposome , microbiology and biotechnology , membrane , motility , in vitro , chemistry , vesicle , membrane protein , biochemistry , biology

Keeping harm at bay : In an in vitro strategy to prevent the cellular motility of oncogenic STAT3 protein, protein–membrane anchorage was induced by the use of a rationally designed cholesterol‐based protein–membrane anchor in breast‐tumor cells. (The fluorescence image shows the localization of the protein to the liposome boundary of a multilamellar vesicle.)

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