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Isoxazole Functionalization Technologies Enable Construction of Tetracycline Derivatives
Author(s) -
Heasley Brian
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102480
Subject(s) - tetracycline , antimicrobial , isoxazole , surface modification , combinatorial chemistry , chemistry , biology , antibiotics , microbiology and biotechnology , stereochemistry
Reactive response : Tetracyclines are potent antimicrobial agents—however, their high consumption level has contributed to the emergence of widespread bacterial resistance, which in turn stimulates the systematic search for new tetracycline analogues. In recent years, new synthetic methods have emerged that provide access to a broad range of tetracycline analogues.