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Towards Direct Mukaiyama‐Type Reactions Catalytic in Silicon
Author(s) -
García Jesús M.,
Oiarbide Mikel,
Palomo Claudio
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102423
Subject(s) - catalysis , silicon , chemistry , carbon fibers , combinatorial chemistry , mannich reaction , organic chemistry , nanotechnology , materials science , composite material , composite number
Direct catalytic enolate generation from unactivated carboxylic acid derivatives may provide new routes for asymmetric carbon–carbon bond formation (see scheme). Recent studies demonstrate the potential of silicon catalysts or promoters in this endeavor, and this is best illustrated by a Mannich‐type reaction of simple amides.