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Highly Enantioselective Catalytic Synthesis of Functionalized Chiral Diazoacetoacetates
Author(s) -
Xu Xinfang,
Hu WenHao,
Doyle Michael P.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102405
Subject(s) - enantioselective synthesis , enantiomer , combinatorial chemistry , lewis acids and bases , chemistry , catalysis , computer science , organic chemistry
In addition : The Mukaiyama–Michael addition in the presence of a chiral copper(II) Lewis acid is a highly enantioselective and efficient method for the construction of a broad range of chiral γ‐functionalized diazoacetoacetates. These products can be conveniently transformed into useful enantiomer‐enriched 1,5‐diesters (see scheme, Np=1‐naphthyl, TBS= tert ‐butyldimethylsilyl).
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