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Continuous‐Flow Synthesis of 3,3‐Disubstituted Oxindoles by a Palladium‐Catalyzed α‐Arylation/Alkylation Sequence
Author(s) -
Li Pengfei,
Buchwald Stephen L.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102401
Subject(s) - microreactor , continuous flow , modular design , sequence (biology) , palladium , flow chemistry , catalysis , chemistry , combinatorial chemistry , alkylation , flow (mathematics) , computer science , key (lock) , organic chemistry , programming language , mathematics , biochemical engineering , engineering , biochemistry , geometry , computer security
Facilitating chemistry : Key to the success of Pd‐catalyzed α‐arylation of oxindoles in continuous flow involved a biphasic system, a precatalyst, and a packed‐bed microreactor. Furthermore, this reaction was integrated into a two‐step continuous‐flow sequence for rapid, modular, and efficient syntheses of 3,3‐disubstituted oxindoles.