Continuous‐Flow Synthesis of 3,3‐Disubstituted Oxindoles by a Palladium‐Catalyzed α‐Arylation/Alkylation Sequence | Zendy

Li Pengfei | Zendy; Buchwald Stephen L. | Zendy

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Continuous‐Flow Synthesis of 3,3‐Disubstituted Oxindoles by a Palladium‐Catalyzed α‐Arylation/Alkylation Sequence

Author(s) -

Li Pengfei,

Buchwald Stephen L.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201102401

Subject(s) - microreactor , continuous flow , modular design , sequence (biology) , palladium , flow chemistry , catalysis , chemistry , combinatorial chemistry , alkylation , flow (mathematics) , computer science , key (lock) , organic chemistry , programming language , mathematics , biochemical engineering , engineering , biochemistry , geometry , computer security

Facilitating chemistry : Key to the success of Pd‐catalyzed α‐arylation of oxindoles in continuous flow involved a biphasic system, a precatalyst, and a packed‐bed microreactor. Furthermore, this reaction was integrated into a two‐step continuous‐flow sequence for rapid, modular, and efficient syntheses of 3,3‐disubstituted oxindoles.

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