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Palladium‐Catalyzed β‐Selective Direct Arylation of Porphyrins
Author(s) -
Kawamata Yu,
Tokuji Sumito,
Yorimitsu Hideki,
Osuka Atsuhiro
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102318
Subject(s) - palladium , catalysis , chemistry , porphyrin , combinatorial chemistry , photochemistry , organic chemistry
Four birds with one stone : A palladium catalyst/potassium carbonate/pivalic acid system enables direct arylation of porphyrins by aryl bromides (see scheme; Ar′=3,5‐ t Bu 2 C 6 H 3 ). The CH arylation shows excellent β selectivity and does not require porphyrin prefunctionalization, hence representing an extremely efficient method for rapidly providing a series of new β‐arylated porphyrins.
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