Asymmetric Autocatalysis: Triggered by Chiral Isotopomer Arising from Oxygen Isotope Substitution | Zendy

Kawasaki Tsuneomi | Zendy; Okano Yasushi | Zendy; Suzuki Etsuharu | Zendy; Takano Shizuka | Zendy; Oji Shotaro | Zendy; Soai Kenso | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Asymmetric Autocatalysis: Triggered by Chiral Isotopomer Arising from Oxygen Isotope Substitution

Author(s) -

Kawasaki Tsuneomi,

Okano Yasushi,

Suzuki Etsuharu,

Takano Shizuka,

Oji Shotaro,

Soai Kenso

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201102263

Subject(s) - autocatalysis , isotopomers , enantioselective synthesis , chemistry , oxygen , chirality (physics) , isotopes of oxygen , substitution (logic) , kinetic isotope effect , stereochemistry , catalysis , organic chemistry , physics , chiral anomaly , nuclear chemistry , molecule , deuterium , computer science , particle physics , quantum mechanics , nambu–jona lasinio model , programming language , fermion

Trigger happy : Chiral oxygen isotopomers of hydrobenzoin ([ 18 O]( R )‐ 1 and [ 18 O]( S )‐ 1 ) acted as chiral triggers to induce the enantioselective addition of i Pr 2 Zn to pyrimidine‐5‐carbaldehyde. An extremely small chiral influence arising from the presence of the oxygen isotope ( 18 O) is amplified through asymmetric autocatalysis to enantioenrich the 5‐pyrimidyl alkanol product.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research