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High‐Density, Multiplexed Patterning of Cells at Single‐Cell Resolution for Tissue Engineering and Other Applications
Author(s) -
Vermesh Udi,
Vermesh Ophir,
Wang Jun,
Kwong Gabriel A.,
Ma Chao,
Hwang Kiwook,
Heath James R.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102249
Subject(s) - multiplexing , tissue engineering , resolution (logic) , materials science , nanotechnology , optoelectronics , computer science , biomedical engineering , engineering , telecommunications , artificial intelligence
Surface chemistry meets tissue engineering : A novel surface‐patterning approach for creating arrays of DNA squares is combined with a unique method for DNA‐encoding of cells to construct dense arrays of distinct single cells. The cell patterns can be transferred from the substrate surface into thin hydrogel films, and these layers can be stacked to form 3D tissue constructs.