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Cover Picture: Oral, Direct Thrombin and Factor Xa Inhibitors: The Replacement for Warfarin, Leeches, and Pig Intestines? (Angew. Chem. Int. Ed. 20/2011)
Author(s) -
Straub Alexander,
Roehrig Susanne,
Hillisch Alexander
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102242
Subject(s) - coagulation cascade , thrombin , int , fibrin , warfarin , factor x , coagulation , chemistry , microbiology and biotechnology , pharmacology , biochemistry , platelet , biology , medicine , immunology , computer science , atrial fibrillation , operating system
The large water cascade (ital. cascare =to fall) in the baroque landscaped park Wilhelmshöhe in Kassel (Germany) is reminiscent of the blood‐clotting cascade in which the different clotting factors initiate the formation of fibrin thrombi in an amplification cascade. This protective mechanism against blood loss is, however, also the cause of thrombotic diseases. In order to inhibit it an extensive search for low‐molecular‐weight factor Xa and thrombin inhibitors has been carried out. More on this in the Review by A. Straub et al. on page 4574 ff.