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Inside Cover: Polyoxometalates as Inhibitors of the Aggregation of Amyloid β Peptides Associated with Alzheimer’s Disease (Angew. Chem. Int. Ed. 18/2011)
Author(s) -
Geng Jie,
Li Meng,
Ren Jinsong,
Wang Enbo,
Qu Xiaogang
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102185
Subject(s) - amyloid β , cover (algebra) , amyloid (mycology) , chemistry , β amyloid , peptide , int , alzheimer's disease , disease , biochemistry , medicine , computer science , engineering , mechanical engineering , inorganic chemistry , operating system
Four types of polyoxometalates (POMs) have been found to be efficient inhibitors of amyloid formation by amyloid β peptides (Aβ) associated with Alzheimer's disease. X. Qu and co‐workers show in their Communication on page 4184 ff. that the inhibition selectivity of the POMs is due to size‐specific electrostatic interactions between the POMs and Aβ, with the POMs binding to the positively charged His13–Lys16 cluster region of Aβ.