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Catalytic Enantioselective Addition of Sodium Bisulfite to Chalcones
Author(s) -
Moccia Maria,
Fini Francesco,
Scagnetti Michela,
Adamo Mauro F. A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102162
Subject(s) - enantioselective synthesis , bifunctional , sodium bisulfite , catalysis , bisulfite , chemistry , organic chemistry , combinatorial chemistry , biochemistry , gene expression , dna methylation , gene
At last! The addition of bisulfite to olefins, discovered over a century ago, remains the most straightforward approach to aliphatic sulfonic acids. A catalytic enantioselective procedure has now been realized that employs a bifunctional aminothiourea catalyst (see picture). Sulfonic acids were obtained from chalcones in high yields and high enantioselectivity and in both configurations.