Highly Diastereoselective and Enantioselective Synthesis of α‐Hydroxy β‐Amino Acid Derivatives: Lewis Base Catalyzed Hydrosilylation of α‐Acetoxy β‐Enamino Esters | Zendy

Jiang Yan | Zendy; Chen Xing | Zendy; Zheng Yongsheng | Zendy; Xue Zhouyang | Zendy; Shu Chang | Zendy; Yuan Weicheng | Zendy; Zhang Xiaomei | Zendy

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Highly Diastereoselective and Enantioselective Synthesis of α‐Hydroxy β‐Amino Acid Derivatives: Lewis Base Catalyzed Hydrosilylation of α‐Acetoxy β‐Enamino Esters

Author(s) -

Jiang Yan,

Chen Xing,

Zheng Yongsheng,

Xue Zhouyang,

Shu Chang,

Yuan Weicheng,

Zhang Xiaomei

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201102150

Subject(s) - hydrosilylation , enantioselective synthesis , lewis acids and bases , catalysis , chemistry , base (topology) , organic chemistry , mathematics , mathematical analysis

By design : A series of α‐acetoxy‐β‐enamino esters 1 were synthesized and then subjected to catalytic asymmetric hydrosilylation. In the presence of a chiral Lewis base catalyst, the reactions proceeded smoothly to provide a wide range of chiral α‐acetoxy β‐amino acid derivatives in high yields with good diastereoselectivities and enantioselectivities.

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