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La/Ag Heterobimetallic Cooperative Catalysis: A Catalytic Asymmetric Conia‐Ene Reaction
Author(s) -
Matsuzawa Akinobu,
Mashiko Tomoyuki,
Kumagai Naoya,
Shibasaki Masakatsu
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102114
Subject(s) - cyclopentane , catalysis , intramolecular force , alkyne , amide , chemistry , ligand (biochemistry) , lewis acids and bases , polymer chemistry , combinatorial chemistry , ene reaction , stereochemistry , organic chemistry , receptor , biochemistry
A dual catalyst system : The cooperative function of a hard and soft Lewis acid (La III and Ag I , respectively) in a catalyst system that includes an amide‐based ligand 1 is crucial for simultaneous activation of intramolecular 1,3‐dicarbonyl and alkyne moieties to afford enantioenriched cyclopentane derivatives (see scheme).