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One‐Pot Synthesis of an 125 I‐Labeled Trifunctional Reagent for Multiscale Imaging with Optical and Nuclear Techniques
Author(s) -
Yan Ran,
ElEmir Ethaar,
Rajkumar Vineeth,
Robson Mathew,
Jathoul Amit P.,
Pedley R. Barbara,
Årstad Erik
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102072
Subject(s) - reagent , dual (grammatical number) , computer science , nuclear imaging , optical imaging , chemistry , combinatorial chemistry , physics , nuclear medicine , optics , organic chemistry , medicine , philosophy , linguistics
A highly efficient and rapid Cu II ‐mediated three‐component “click reaction” allows one‐pot assembly of dual optical and nuclear labeling reagents. Proof‐of‐concept imaging studies demonstrate that the distribution of the dual‐labeled antibody A5B7 can be interrogated from the cellular to the macroscopic level using a combination of optical and nuclear imaging techniques.