Premium
Split Personality of Lithium Chloride: Recent Salt Effects in Organometallic Recipes
Author(s) -
Hevia Eva,
Mulvey Robert E.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102054
Subject(s) - chemistry , salt (chemistry) , reagent , lithium diisopropylamide , lithium (medication) , reactivity (psychology) , metathesis , chloride , catalysis , lithium chloride , organic chemistry , halogen , group 2 organometallic chemistry , molecule , ion , psychology , alkyl , medicine , alternative medicine , pathology , deprotonation , polymerization , polymer , psychiatry
Jekyll and Hyde : Pinches of LiCl can catalyze orthometalations of halogen‐substituted arenes and addition reactions of unsaturated esters, mediated by lithium diisopropylamide. Larger salt portions can transform weak organometallic bases (e.g., Grignard reagents, zincates) into “turbo” reagents of high reactivity and functional group tolerance. But the presence of LiCl, especially as an overlooked metathesis by‐product can be detrimental to other catalytic reactions.