Dynamic One‐Pot Three‐Component Catalytic Asymmetric Transformation by Combination of Hydrogen‐Bond‐Donating and Amine Catalysts | Zendy

Lin Shuangzheng | Zendy; Deiana Luca | Zendy; Zhao GuiLing | Zendy; Sun Junliang | Zendy; Córdova Armando | Zendy

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Dynamic One‐Pot Three‐Component Catalytic Asymmetric Transformation by Combination of Hydrogen‐Bond‐Donating and Amine Catalysts

Author(s) -

Lin Shuangzheng,

Deiana Luca,

Zhao GuiLing,

Sun Junliang,

Córdova Armando

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201101966

Subject(s) - stereocenter , catalysis , amine gas treating , component (thermodynamics) , chemistry , organic chemistry , hydrogen bond , transformation (genetics) , combinatorial chemistry , enantioselective synthesis , molecule , biochemistry , physics , gene , thermodynamics

In control : The first dynamic one‐pot three‐component asymmetric transformation between aldehydes, protected α‐cyanoglycine esters, and enals catalyzed by a combination of a simple hydrogen‐bond‐donating catalyst and a chiral amine catalyst is disclosed. Polysubstituted proline derivatives, which have a quaternary α stereocenter, were synthesized with high endo ‐, diastereo‐, and enantioselectivities (93–99 % ee ).

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