Premium
Ruthenium‐Catalyzed Oxidative Annulation by Cleavage of CH/NH Bonds
Author(s) -
Ackermann Lutz,
Lygin Alexander V.,
Hofmann Nora
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101943
Bond activation in action : Unprecedented ruthenium‐catalyzed oxidative annulations of alkynes through cleavage of CH bonds set the stage for an efficient 1(2 H )‐isoquinolone synthesis with ample scope (see scheme; t Am= tert ‐amyl). Mechanistic studies provided strong evidence for a rate‐limiting CH bond metalation through carboxylate assistance.