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The Catalytic Enantioselective Total Synthesis of (+)‐Liphagal
Author(s) -
Day Joshua J.,
McFadden Ryan M.,
Virgil Scott C.,
Kolding Helene,
Alleva Jennifer L.,
Stoltz Brian M.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101842
Subject(s) - enantioselective synthesis , total synthesis , ring (chemistry) , stereoselectivity , natural product , catalysis , chemistry , combinatorial chemistry , stereochemistry , organic chemistry
Ring a ding : The meroterpenoid natural product (+)‐liphagal has been synthesized enantioselectively in 19 steps from commercially available materials. The trans ‐homodecalin system was achieved by ring expansion followed by stereoselective hydrogenation.