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Dual Hydrogen‐Bond/Enamine Catalysis Enables a Direct Enantioselective Three‐Component Domino Reaction
Author(s) -
Rahaman Hasibur,
Madarász Ádám,
Pápai Imre,
Pihko Petri M.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101835
Subject(s) - enantioselective synthesis , enamine , nitromethane , chemistry , catalysis , organocatalysis , combinatorial chemistry , domino , hydrogen bond , dual (grammatical number) , organic chemistry , molecule , art , literature
It takes two to tango : A dual catalyst system, composed of a highly enantioselective enamine catalyst and a multiple‐hydrogen‐bond catalyst, enabled the chemoselective union of two aldehydes and a nitromethane unit with near‐perfect enantioselectivities, excellent diastereoselectivities, and high yields under neutral conditions (see scheme).