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Cobalt–Phenanthroline Catalysts for the ortho Alkylation of Aromatic Imines under Mild Reaction Conditions
Author(s) -
Gao Ke,
Yoshikai Naohiko
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101823
Subject(s) - catalysis , alkylation , cobalt , phenanthroline , reagent , chemistry , combinatorial chemistry , organic chemistry , medicinal chemistry
Mild mannered : Cobalt catalysts complexed with phenanthroline‐type ligands and activated with Grignard reagents serve as inexpensive and effective catalysts for the ortho alkylation of aromatic imines with a variety of olefins (see scheme). The new catalytic systems feature remarkably mild reaction conditions for CH bond activation and functionalization.