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Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study
Author(s) -
BesanceneyWebler Christen,
Jiang Hao,
Zheng Tianqing,
Feng Lei,
Soriano del Amo David,
Wang Wei,
Klivansky Liana M.,
Marlow Florence L.,
Liu Yi,
Wu Peng
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101817
Subject(s) - bioconjugation , bioorthogonal chemistry , click chemistry , chemistry , cycloaddition , biocompatible material , combinatorial chemistry , azide , nanotechnology , organic chemistry , catalysis , materials science , biomedical engineering , medicine
Raising the bar : The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper‐catalyzed azide–alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.