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Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery
Author(s) -
Svensen Nina,
DíazMochón Juan José,
Dhaliwal Kevin,
Plath Songsak,
Dewar Michael,
Armstrong J. Douglas,
Bradley Mark
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101804
Subject(s) - homing (biology) , peptide , peptide library , peptide nucleic acid , computational biology , nucleic acid , cell , identification (biology) , chemistry , biology , peptide sequence , biochemistry , gene , ecology , botany
To the point : The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell‐selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)‐encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest.