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Residual Chemical Shift Anisotropy (RCSA): A Tool for the Analysis of the Configuration of Small Molecules
Author(s) -
Hallwass Fernando,
Schmidt Manuel,
Sun Han,
Mazur Adam,
Kummerlöwe Grit,
Luy Burkhard,
NavarroVázquez Armando,
Griesinger Christian,
Reinscheid Uwe M.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101784
Subject(s) - residual , anisotropy , diastereomer , residual dipolar coupling , molecule , dipole , computer science , symmetry (geometry) , chemistry , chemical physics , computational chemistry , physics , algorithm , stereochemistry , organic chemistry , mathematics , optics , geometry
Together we are strong : A new, robust method allows the measurement of residual chemical shift anisotropies for the determination of conformation and configuration of molecules in organic solvents. The power of the method is shown by the example of estrone and 13‐ epi ‐estrone (see structures), where only the combined use of residual chemical shift anisotropies and residual dipolar couplings leads to the distinction of the two diastereomers.