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Multifunctional Nanoparticles for Targeted Chemophotothermal Treatment of Cancer Cells
Author(s) -
Lee SunMi,
Park Huiyul,
Choi JoungWoo,
Park Young Nyun,
Yun ChaeOk,
Yoo KyungHwa
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101783
Subject(s) - plga , conjugated system , nanoparticle , ethylene glycol , glycolic acid , doxorubicin , drug delivery , chemistry , nanotechnology , cancer research , materials science , lactic acid , medicine , polymer , chemotherapy , organic chemistry , surgery , biology , bacteria , genetics
Drug and heat delivery to tumors by active targeting with Herceptin‐conjugated doxorubicin‐loaded poly(ethylene glycol)–poly(lactic‐ co ‐glycolic acid)–Au half‐shell nanoparticles (HER‐DOX‐PLGA‐Au H‐S NPs) is more effective than passive targeting with their HER‐free counterparts (DOX‐PLGA‐Au H‐S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor‐bearing mice that were treated with the HER‐conjugated particles (see picture).