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Kinetic and Thermodynamic Control of G‐Quadruplex Folding
Author(s) -
Xue Yong,
Liu Jiaquan,
Zheng Kewei,
Kan Zhongyuan,
Hao Yuhua,
Tan Zheng
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101759
Subject(s) - antiparallel (mathematics) , g quadruplex , telomere , computer science , guanine , chemistry , dna , computational biology , crystallography , biochemistry , physics , biology , nucleotide , quantum mechanics , magnetic field , gene
A matter of speed : When allowed to fold in a K + /poly(ethylene glycol) solution, the guanine (G)‐rich strand of vertebrate telomere DNA forms a parallel/antiparallel G‐quadruplex, which is a (3+1) hybrid, within microseconds before slowly transforming into the parallel one within hours (see picture). Thus, the conformation that a G‐quadruplex initially adopts under physiological conditions may not be the one it adopts at the equilibrium state.