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Gold Nanoparticles Presenting Hybridized Self‐Assembled Aptamers That Exhibit Enhanced Inhibition of Thrombin
Author(s) -
Shiang YenChun,
Hsu ChiaLun,
Huang ChihChing,
Chang HuanTsung
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101718
Subject(s) - aptamer , thrombin , monolayer , nanoparticle , flexibility (engineering) , chemistry , nanotechnology , colloidal gold , computational biology , dna , combinatorial chemistry , biophysics , computer science , microbiology and biotechnology , biochemistry , materials science , biology , platelet , statistics , mathematics , immunology
DNA hybridization of thrombin‐binding aptamers (TBAs) to form a self‐assembled arranged monolayer on gold nanoparticles (Au NPs) was used to control the coagulation activity of thrombin. The hTBA 15 /hTBA 29 /cDNA‐Au NPs provided flexibility and a suitable orientation and distance between the hTBA 15 and hTBA 29 units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.