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Template‐Induced Screw Motions within an Aromatic Amide Foldamer Double Helix
Author(s) -
Ferrand Yann,
Gan Quan,
Kauffmann Brice,
Jiang Hua,
Huc Ivan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101697
Subject(s) - foldamer , duplex (building) , amide , hydrogen bond , helix (gastropod) , crystallography , solid state , chemistry , stereochemistry , molecule , organic chemistry , dna , ecology , biochemistry , snail , biology
Screwed in place : An anti‐parallel double‐helical aromatic oligoamide foldamer was shown to bind to a series of rodlike guests of various lengths upon the winding of the duplex around the guests (see scheme). Solid‐state crystal structures of the host–guest complexes show that the two strands of the duplex undergo a relative screw motion to adjust the distance between hydrogen‐bond donors located at the end of one of their extremities so that they bind to hydrogen‐bond acceptors of the guest.