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Noninvasive Photoacoustic Microscopy of Living Cells in Two and Three Dimensions through Enhancement by a Metabolite Dye
Author(s) -
Zhang Yu,
Cai Xin,
Wang Yu,
Zhang Chi,
Li Li,
Choi SungWook,
Wang Lihong V.,
Xia Younan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101659
Subject(s) - contrast (vision) , photoacoustic imaging in biomedicine , metabolite , microscopy , formazan , high contrast , tumor cells , chemistry , nanotechnology , computer science , biophysics , materials science , pathology , medicine , biology , biochemistry , optics , physics , cancer research , artificial intelligence
Rich in contrast : A new type of contrast agent, 1‐(4,5‐dimethyl‐2‐thiazolyl)‐3,5‐diphenylformazan (MTT formazan), is reported for nondestructive and nontoxic imaging of living cells by photoacoustic microscopy (see picture). The contrast mechanism is general and can be applied to essentially all types of metabolically active cells, including stem cells and tumor cells.