Premium
Palladium‐Catalyzed CC Bond Formation To Construct 1,4‐Diketones under Mild Conditions
Author(s) -
Liu Chao,
Deng Yi,
Wang Jing,
Yang Yingying,
Tang Shan,
Lei Aiwen
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101638
Subject(s) - palladium , ketone , electrophile , nucleophile , chemistry , catalysis , zinc , medicinal chemistry , organic chemistry , combinatorial chemistry
Palladium can do it! A novel palladium‐catalyzed reaction between the bulky α‐carbon centers of two ketones has led to the construction of 2,3‐diaryl‐1,4‐diketones by employing α‐chloroketones as electrophiles and zinc ketone enolates as nucleophiles (see scheme). This reaction allows the synthesis of bulky 1,4‐diketones and is complementary with classic nucleophilic substitution reactions.