Palladium‐Catalyzed CC Bond Formation To Construct 1,4‐Diketones under Mild Conditions | Zendy

Liu Chao | Zendy; Deng Yi | Zendy; Wang Jing | Zendy; Yang Yingying | Zendy; Tang Shan | Zendy; Lei Aiwen | Zendy

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Palladium‐Catalyzed CC Bond Formation To Construct 1,4‐Diketones under Mild Conditions

Author(s) -

Liu Chao,

Deng Yi,

Wang Jing,

Yang Yingying,

Tang Shan,

Lei Aiwen

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201101638

Subject(s) - palladium , ketone , electrophile , nucleophile , chemistry , catalysis , zinc , medicinal chemistry , organic chemistry , combinatorial chemistry

Palladium can do it! A novel palladium‐catalyzed reaction between the bulky α‐carbon centers of two ketones has led to the construction of 2,3‐diaryl‐1,4‐diketones by employing α‐chloroketones as electrophiles and zinc ketone enolates as nucleophiles (see scheme). This reaction allows the synthesis of bulky 1,4‐diketones and is complementary with classic nucleophilic substitution reactions.

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