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Bio‐orthogonal “Double‐Click” Chemistry Based on Multifunctional Coatings
Author(s) -
Deng Xiaopei,
Friedmann Christian,
Lahann Joerg
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101581
Subject(s) - click chemistry , reactivity (psychology) , catalysis , chemistry , combinatorial chemistry , computer science , nanotechnology , organic chemistry , materials science , medicine , alternative medicine , pathology
Double “click” : Two different molecules can be sequentially immobilized on defined areas of the same surface by utilizing the different reactivity of activated and non‐activated alkynyl groups (see picture). The reactions were carried out at room temperature in water, with the first immobilization step being catalyst‐free and the second step requiring Cu I as a catalyst.