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A Potent Trivalent Sialic Acid Inhibitor of Adenovirus Type 37 Infection of Human Corneal Cells
Author(s) -
Spjut Sara,
Qian Weixing,
Bauer Johannes,
Storm Rickard,
Frängsmyr Lars,
Stehle Thilo,
Arnberg Niklas,
Elofsson Mikael
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101559
Subject(s) - sialic acid , chemistry , microbiology and biotechnology , biochemistry , biology
Wouldn′t it be useful to have three arms? It came in handy for a trivalent sialic acid inhibitor, which blocked all three binding pockets of a trimeric adenoviral fiber‐knob protein and thus prevented cell attachment and the subsequent infection of human corneal epithelial cells. The picture shows the terminal sialic acid moietes of the inhibitor bound to the top of the fiber head (C yellow, O red, N blue; the spacers and scaffold are not shown).