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Stereoselective Synthesis of Highly Substituted Enamides by an Oxidative Heck Reaction
Author(s) -
Liu Yu,
Li Dan,
Park CheolMin
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101550
Subject(s) - heck reaction , reactivity (psychology) , stereoselectivity , oxidative phosphorylation , chemistry , surface modification , coupling reaction , combinatorial chemistry , organic chemistry , catalysis , palladium , biochemistry , medicine , alternative medicine , pathology
Functionalization of enamides under Heck conditions has been limited to those with unsubstituted vinyl groups. By tuning reaction parameters that allow for the balance between stability and reactivity of reactants, the oxidative Heck cross‐coupling to produce highly substituted enamides in good to excellent yields was achieved (see scheme).