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Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel‐Forming Peptide
Author(s) -
Matsuoka Shigeru,
Shinohara Naoki,
Takahashi Tomoaki,
Iida Maiko,
Inoue Masayuki
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101533
Subject(s) - peptide , channel (broadcasting) , transmembrane protein , sequence (biology) , computational biology , computer science , information retrieval , chemistry , combinatorial chemistry , biology , stereochemistry , biochemistry , telecommunications , receptor
Longer is better: Polytheonamide B, the largest nonribosomal linear peptide identified to date, is a transmembrane channel‐forming peptide. Nine of its substructures have now been chemically synthesized. The membrane‐disrupting and ion‐channel‐forming sequences as well as the cytotoxicity‐enhancing sequence have been identified.