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Multiple‐Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles
Author(s) -
Ling Daishun,
Park Wooram,
Park Yong Il,
Lee Nohyun,
Li Fangyuan,
Song Changyeong,
Yang SuGeun,
Choi Seung Hong,
Na Kun,
Hyeon Taeghwan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101521
Subject(s) - biocompatible material , nanoparticle , ligand (biochemistry) , nanotechnology , aqueous medium , adhesive , chemistry , aqueous solution , combinatorial chemistry , computer science , materials science , organic chemistry , biochemistry , engineering , biomedical engineering , layer (electronics) , receptor
All bound up : A poly( L ‐3,4‐dihydroxyphenylalanine)‐based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this ligand (see picture) are highly stable in various aqueous solutions. A successful in vivo MRI application using functionalized Fe 3 O 4 nanoparticles confirmed their suitability for various biomedical applications.