Multiple‐Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles | Zendy

Ling Daishun | Zendy; Park Wooram | Zendy; Park Yong Il | Zendy; Lee Nohyun | Zendy; Li Fangyuan | Zendy; Song Changyeong | Zendy; Yang SuGeun | Zendy; Choi Seung Hong | Zendy; Na Kun | Zendy; Hyeon Taeghwan | Zendy

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Multiple‐Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles

Author(s) -

Ling Daishun,

Park Wooram,

Park Yong Il,

Lee Nohyun,

Li Fangyuan,

Song Changyeong,

Yang SuGeun,

Choi Seung Hong,

Na Kun,

Hyeon Taeghwan

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201101521

Subject(s) - biocompatible material , nanoparticle , ligand (biochemistry) , nanotechnology , aqueous medium , adhesive , chemistry , aqueous solution , combinatorial chemistry , computer science , materials science , organic chemistry , biochemistry , engineering , biomedical engineering , layer (electronics) , receptor

All bound up : A poly( L ‐3,4‐dihydroxyphenylalanine)‐based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this ligand (see picture) are highly stable in various aqueous solutions. A successful in vivo MRI application using functionalized Fe 3 O 4 nanoparticles confirmed their suitability for various biomedical applications.

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