Disrupting the Reader of Histone Language | Zendy

Oliver Samuel S. | Zendy; Denu John M. | Zendy

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Disrupting the Reader of Histone Language

Author(s) -

Oliver Samuel S.,

Denu John M.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201101414

Subject(s) - bromodomain , epigenetics , histone , chromatin , context (archaeology) , computational biology , chemistry , microbiology and biotechnology , biology , biochemistry , gene , paleontology

New targets, new drugs : In the context of regulating gene expression, small molecules have been found that specifically disrupt the interaction between the “reader” (e.g. a protein with a bromodomain) and chromatin. These results provide compelling proof‐of‐concept that disrupting histone readers is a viable strategy for the development of epigenetic drugs. (The picture shows the complex formed by (+)‐JQ1 and the bromodomain hBRD2.)

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