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Disrupting the Reader of Histone Language
Author(s) -
Oliver Samuel S.,
Denu John M.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101414
Subject(s) - bromodomain , epigenetics , histone , chromatin , context (archaeology) , computational biology , chemistry , microbiology and biotechnology , biology , biochemistry , gene , paleontology
New targets, new drugs : In the context of regulating gene expression, small molecules have been found that specifically disrupt the interaction between the “reader” (e.g. a protein with a bromodomain) and chromatin. These results provide compelling proof‐of‐concept that disrupting histone readers is a viable strategy for the development of epigenetic drugs. (The picture shows the complex formed by (+)‐JQ1 and the bromodomain hBRD2.)