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Dual Ti–Ru Catalysis in the Direct Radical Haloalkylation of N ‐Acyl Oxazolidinones
Author(s) -
Gu Zhenhua,
Herrmann Aaron T.,
Zakarian Armen
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101364
Subject(s) - ruthenium , catalysis , titanium , amine gas treating , chemistry , combinatorial chemistry , organic chemistry
Waste not, want not : A mechanistic study of the ruthenium‐catalyzed haloalkylation of titanium enolates led to the development of a process that is catalytic in both metals: titanium and ruthenium (see scheme; Bn=benzyl, PMP=1,2,2,6,6‐pentamethylpiperidine). Catalytic turnover was observed in the formation of the titanium enolates from N ‐acyl oxazolidinones, and insight was gained into the inhibitory effect of the amine base.