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Graphene Oxide–Peptide Conjugate as an Intracellular Protease Sensor for Caspase‐3 Activation Imaging in Live Cells
Author(s) -
Wang Haibo,
Zhang Qing,
Chu Xia,
Chen Tingting,
Ge Jia,
Yu Ruqin
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101351
Subject(s) - conjugate , intracellular , peptide , fluorophore , graphene , protease , nanotechnology , chemistry , biophysics , computer science , biochemistry , biology , materials science , physics , fluorescence , enzyme , optics , mathematical analysis , mathematics
All systems GO! An intracellular protease sensor is based on the covalent conjugate of graphene oxide and peptide substrates with fluorophore labels. The conjugate can be delivered into live cells and provides specific, high‐contrast imaging of caspase‐3 activation (see picture; orange=cell penetration peptide, blue/black=caspase‐3 peptide probe).