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Thermoresponsive Chlorambucil Derivatives for Tumour Targeting
Author(s) -
Clavel Catherine M.,
Zava Olivier,
Schmitt Frédéric,
Halamoda Kenzaoui Blanka,
Nazarov Alexey A.,
JuilleratJeanneret Lucienne,
Dyson Paul J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101133
Subject(s) - chlorambucil , computer science , cancer research , chemistry , combinatorial chemistry , chemotherapy , medicine , cyclophosphamide
Putting the heat on : Drugs that are essentially inactive at 37 °C and are active under mild hyperthermia can be synthesized by modification of chlorambucil with thermoresponsive groups (see picture; C gray, Cl green, F yellow, H white, N blue, O red). This modification should allow this cytotoxic agent to be used in a more targeted fashion, and consequently, with reduced side‐effects.