Thermoresponsive Chlorambucil Derivatives for Tumour Targeting | Zendy

Clavel Catherine M. | Zendy; Zava Olivier | Zendy; Schmitt Frédéric | Zendy; Halamoda Kenzaoui Blanka | Zendy; Nazarov Alexey A. | Zendy; JuilleratJeanneret Lucienne | Zendy; Dyson Paul J. | Zendy

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Thermoresponsive Chlorambucil Derivatives for Tumour Targeting

Author(s) -

Clavel Catherine M.,

Zava Olivier,

Schmitt Frédéric,

Halamoda Kenzaoui Blanka,

Nazarov Alexey A.,

JuilleratJeanneret Lucienne,

Dyson Paul J.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201101133

Subject(s) - chlorambucil , computer science , cancer research , chemistry , combinatorial chemistry , chemotherapy , medicine , cyclophosphamide

Putting the heat on : Drugs that are essentially inactive at 37 °C and are active under mild hyperthermia can be synthesized by modification of chlorambucil with thermoresponsive groups (see picture; C gray, Cl green, F yellow, H white, N blue, O red). This modification should allow this cytotoxic agent to be used in a more targeted fashion, and consequently, with reduced side‐effects.

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