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Ruthenium‐Catalyzed Regio‐ and Enantioselective Allylic Substitution with Water: Direct Synthesis of Chiral Allylic Alcohols
Author(s) -
Kanbayashi Naoya,
Onitsuka Kiyotaka
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101078
Subject(s) - allylic rearrangement , enantioselective synthesis , cyclopentadienyl complex , ruthenium , substitution (logic) , catalysis , chemistry , substitution reaction , combinatorial chemistry , organic chemistry , computer science , programming language
Less is more : A new route to access chiral allylic alcohols through the regio‐ and enantioselective substitution of monosubstituted allylic chlorides with water has been developed. The reaction is catalyzed effectively by planar‐chiral cyclopentadienyl ruthenium complexes (see scheme).