Premium
Zirconium‐Catalyzed Multistep Reaction of Hydrazines with Alkynes: A Non‐Fischer‐Type Pathway to Indoles
Author(s) -
Gehrmann Thorsten,
Lloret Fillol Julio,
Scholl Solveig A.,
Wadepohl Hubert,
Gade Lutz H.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101070
Subject(s) - zirconium , indole test , catalysis , chemistry , cascade , combinatorial chemistry , organic chemistry , chromatography
Dominos at zirconium : A cascade of N–N and C–H scissions and C–C and C–N coupling steps in the coordination sphere of zirconium directly converts alkynes and hydrazines into indoles. The reaction pathway differs fundamentally from that of the Fischer indole synthesis.