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Random‐Coil:α‐Helix Equilibria as a Reporter for the Lewis X –Lewis X Interaction
Author(s) -
Altamore Timothy M.,
FernándezGarcía Christian,
Gordon Andrew H.,
Hübscher Tina,
Promsawan Netnapa,
Ryadnov Maxim G.,
Doig Andrew J.,
Woolfson Derek N.,
Gallagher Timothy
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101055
Subject(s) - chemistry , lactose , random coil , helix (gastropod) , trisaccharide , carbohydrate , peptide , stereochemistry , food science , biochemistry , circular dichroism , ecology , snail , biology
Probing weak interactions : A peptide random‐coil:α‐helix equilibrium has been used to identify a weak carbohydrate–carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation.