Stereodivergent Direct Catalytic Asymmetric Mannich‐Type Reactions of α‐Isothiocyanato Ester with Ketimines | Zendy

Lu Gang | Zendy; Yoshino Tatsuhiko | Zendy; Morimoto Hiroyuki | Zendy; Matsunaga Shigeki | Zendy; Shibasaki Masakatsu | Zendy

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Stereodivergent Direct Catalytic Asymmetric Mannich‐Type Reactions of α‐Isothiocyanato Ester with Ketimines

Author(s) -

Lu Gang,

Yoshino Tatsuhiko,

Morimoto Hiroyuki,

Matsunaga Shigeki,

Shibasaki Masakatsu

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201101034

Subject(s) - stereocenter , steric effects , catalysis , chemistry , vicinal , asymmetric carbon , type (biology) , stereochemistry , enantioselective synthesis , combinatorial chemistry , organic chemistry , optically active , ecology , biology

Now accessible : Sterically hindered vicinal tetrasubstituted carbon stereocenters, which are not accessible by asymmetric hydrogenation, were constructed by a catalytic asymmetric CC bond formation (see scheme; Dpp=diphenylphosphinoyl). By changing the Group 2 metal center, stereodivergent access to α,β‐tetrasubstituted α,β‐diamino esters was realized.

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