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Stereodivergent Direct Catalytic Asymmetric Mannich‐Type Reactions of α‐Isothiocyanato Ester with Ketimines
Author(s) -
Lu Gang,
Yoshino Tatsuhiko,
Morimoto Hiroyuki,
Matsunaga Shigeki,
Shibasaki Masakatsu
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101034
Subject(s) - stereocenter , steric effects , catalysis , chemistry , vicinal , asymmetric carbon , type (biology) , stereochemistry , enantioselective synthesis , combinatorial chemistry , organic chemistry , optically active , ecology , biology
Now accessible : Sterically hindered vicinal tetrasubstituted carbon stereocenters, which are not accessible by asymmetric hydrogenation, were constructed by a catalytic asymmetric CC bond formation (see scheme; Dpp=diphenylphosphinoyl). By changing the Group 2 metal center, stereodivergent access to α,β‐tetrasubstituted α,β‐diamino esters was realized.