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High‐Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush‐Like Copolymers Produced by ROMP
Author(s) -
Miki Koji,
Kimura Akinori,
Oride Kazuaki,
Kuramochi Yoshiaki,
Matsuoka Hideki,
Harada Hiroshi,
Hiraoka Masahiro,
Ohe Kouichi
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201101005
Subject(s) - amphiphile , copolymer , nanoparticle , fluorescence , romp , polymer , materials science , polymer chemistry , biophysics , chemistry , nanotechnology , polymerization , organic chemistry , physics , metathesis , quantum mechanics , biology
Nanoparticles at work : High‐contrast tumor imaging of mice was performed by using copolymers with hydrophobic and hydrophilic polymer brushes that form cross‐linked assemblies and show a highly stable core surface in aqueous media (see picture). Cyclic RGD peptides and glucosamine moieties were localized on the surface of the assemblies and acted as targeting agents (TA) that enhanced the accumulation of the assemblies in tumor tissues.