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Rhodium‐Catalyzed Branched‐Selective Alkyne Hydroacylation: A Ligand‐Controlled Regioselectivity Switch
Author(s) -
GonzálezRodríguez Carlos,
Pawley Rebekah J.,
Chaplin Adrian B.,
Thompson Amber L.,
Weller Andrew S.,
Willis Michael C.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100956
Subject(s) - hydroacylation , alkyne , regioselectivity , ligand (biochemistry) , rhodium , phosphine , chemistry , aryl , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , receptor , alkyl , biochemistry
It's all in the ligand : By choice of the appropriate diphosphine ligand a previously linear‐selective alkyne hydroacylation process can be “switched” to be highly branched‐selective (see scheme, l=linear, b=branched). Structural data for the ortho ‐ i Pr‐dppe–rhodium catalyst suggest restricted rotation of the phosphine aryl units may be responsible for the observed selectivity.