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Hypersensitive Response to Over‐reactive Cysteines
Author(s) -
Hoogendoorn Sascha,
Willems Lianne,
Florea Bogdan,
Overkleeft Herman
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100938
Subject(s) - proteome , proteomics , cysteine , computational biology , chemistry , amino acid , biochemistry , biology , enzyme , gene
Finding the active cysteine in a hay stack : In the search for active proteins and active‐site peptides in a proteome, techniques such as quantitative proteomics and protein profiling with activity‐based probes (ABPs; see picture) are commonly used. A recently developed proteomics technique combines these approaches to globally identify reactive cysteines, and possibly other amino acids, in a complex proteome.