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A Mitochondrial Surface‐Specific Fluorescent Probe Activated by Bioconversion
Author(s) -
Kawazoe Yoshinori,
Shimogawa Hiroki,
Sato Ayato,
Uesugi Motonari
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100935
Subject(s) - bioconversion , fluorescence , biochemistry , computational biology , chemistry , biology , information retrieval , computer science , optics , physics , fermentation
Cell‐based image screening of 12 000 small molecules with aromatic groups was carried out, and 31 were identified as having potential as fluorescent probes for living cells. One candidate is the first fluorescent probe that specifically stains mitochondrial surfaces. Spectroscopic analyses indicate that the molecule undergoes bioconversion to be fluorescent within cells.