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Near‐Infrared‐Fluorescence‐Enhanced Molecular Imaging of Live Cells on Gold Substrates
Author(s) -
Hong Guosong,
Tabakman Scott M.,
Welsher Kevin,
Chen Zhuo,
Robinson Joshua T.,
Wang Hailiang,
Zhang Bo,
Dai Hongjie
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201100934
Subject(s) - fluorophore , fluorescence , plasmon , nanotechnology , microscopy , infrared , fluorescence microscope , substrate (aquarium) , materials science , optoelectronics , optics , biology , physics , ecology
In the best light : Plasmonic gold substrates were used to image cells by near‐infrared fluorescence microscopy. Two fluorophores (single‐walled carbon nanotubes (SWNTs) functionalized by the RGD sequence as well as the organic fluorophore IR800) tag cells in two different spectral regions. The fluorescence of SWNTs sandwiched between a cell membrane and a gold film was enhanced relative to the fluorescence observed on a quartz substrate (see picture).